My research focuses on the biology and therapy of hemoglobinopathies, the molecular mechanisms underpinning hematopoiesis and the development of the leukemia stem cell, and the transcriptional mechanisms operative during the development of vertebrate organisms. Research projects include characterization of the key factors modulating developmental erythropoiesis, identification of gene regulatory networks in the neural crest and in neuroblastoma, and the development of allogenic stem cell transplant approaches to sickle cell disease. We collaborate with colleagues in developmental biology, informatics, and cancer biology to ensure that we bring a comprehensive perspective to the fundamental question we seek to solve.
Clinical Hematology Branch, National Heart Lung and Blood Institute
National Institutes of Health, Bethesda, MD
- Hematology
1993
Royal Free Hospital School of Medicine
London, United Kingdom
- Wellcome Fellowship, Hematology
1991
Kings College London
United Kingdom
MSc - Biochemistry
1990
Mater Misericordiae Hospital
Dublin, Ireland
- Hematology Fellowship
1987
Royal College of Physicians
United Kingdom
Membership (MRCP) - Medicine
1986
St Laurences Hospital
Dublin, Ireland
- Residency
1985
University College Dublin
Ireland
MB BCh BAO - Medicine
1982
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS).
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS). J Biol Chem. 2026 Apr; 302(4):111278.
PMID: 41690590
Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia.
Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia. Cell Chem Biol. 2026 Jan 15; 33(1):59-73.e10.
PMID: 41500224
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma. Cancer Discov. 2025 Feb 07; 15(2):401-426.
PMID: 39476412
GamblingLess: A Randomised Trial Comparing Guided and Unguided Internet-Based Gambling Interventions.
GamblingLess: A Randomised Trial Comparing Guided and Unguided Internet-Based Gambling Interventions. J Clin Med. 2021 May 21; 10(11).
PMID: 34063826
Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma.
Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma. Genes (Basel). 2021 03 09; 12(3).
PMID: 33803184
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma. J Clin Invest. 2021 01 04; 131(1).
PMID: 32970633
Nucleus preservation in early Ediacaran Weng'an embryo-like fossils, experimental taphonomy of nuclei and implications for reading the eukaryote fossil record.
Nucleus preservation in early Ediacaran Weng'an embryo-like fossils, experimental taphonomy of nuclei and implications for reading the eukaryote fossil record. Interface Focus. 2020 Aug 06; 10(4):20200015.
PMID: 32637068
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 02; 25(2):301-311.
PMID: 30643286
Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant.
Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant. Exp Hematol Oncol. 2019; 8:1.
PMID: 30622841
CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs.
CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs. Bioinformatics. 2018 09 01; 34(17):i664-i670.
PMID: 30423099
Bucksbaum Senior Fellow
Bucksbaum Institute, University of Chicago
2017 - 2019
George M. Eisenberg Professor
University of Chicago
2017 - 2019
Pritzker Professor
University of Chicago
2015 - 2017
Fogarty Fellowship
National Institutes of Health
1991 - 1993
Wellcome Fellowship
Wellcome Trust
1988 - 1991