The Fehon laboratory studies the organization and function of signaling pathway components at the cell cortex, particularly relating to the Hippo growth control pathway. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.
Yale University
New Haven, CT
Postdoctoral - Developmental Genetics
1991
University of Washington
Seattle, WA
PhD - Developmental Biology
1986
Duke University
Durham, NC
BS - Zoology
1980
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth. bioRxiv. 2024 Aug 28.
PMID: 38948705
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP.
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP. Mol Biol Cell. 2024 Oct 01; 35(10):mr8.
PMID: 39141403
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP.
Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP. bioRxiv. 2024 Jan 26.
PMID: 38328041
Cortical tension promotes Kibra degradation via Par-1.
Cortical tension promotes Kibra degradation via Par-1. Mol Biol Cell. 2024 Jan 01; 35(1):ar2.
PMID: 37903240
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling. Dev Cell. 2023 10 09; 58(19):1864-1879.e4.
PMID: 37729921
Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription. Elife. 2021 02 08; 10.
PMID: 33555257
Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos.
Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos. Elife. 2020 11 17; 9.
PMID: 33200987
The CAF-1 complex couples Hippo pathway target gene expression and DNA replication.
The CAF-1 complex couples Hippo pathway target gene expression and DNA replication. Mol Biol Cell. 2019 11 01; 30(23):2929-2942.
PMID: 31553691
Live Imaging of Hippo Pathway Components in Drosophila Imaginal Discs.
Live Imaging of Hippo Pathway Components in Drosophila Imaginal Discs. Methods Mol Biol. 2019; 1893:53-59.
PMID: 30565124
Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner.
Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Dev Cell. 2018 08 06; 46(3):271-284.e5.
PMID: 30032991