My research focuses on the biology and therapy of hemoglobinopathies, the molecular mechanisms underpinning hematopoiesis and the development of the leukemia stem cell, and the transcriptional mechanisms operative during the development of vertebrate organisms. Research projects include characterization of the key factors modulating developmental erythropoiesis, identification of gene regulatory networks in the neural crest and in neuroblastoma, and the development of allogenic stem cell transplant approaches to sickle cell disease. We collaborate with colleagues in developmental biology, informatics, and cancer biology to ensure that we bring a comprehensive perspective to the fundamental question we seek to solve.
Clinical Hematology Branch, National Heart Lung and Blood Institute
National Institutes of Health, Bethesda, MD
- Hematology
1993
Royal Free Hospital School of Medicine
London, United Kingdom
- Wellcome Fellowship, Hematology
1991
Kings College London
United Kingdom
MSc - Biochemistry
1990
Mater Misericordiae Hospital
Dublin, Ireland
- Hematology Fellowship
1987
Royal College of Physicians
United Kingdom
Membership (MRCP) - Medicine
1986
St Laurences Hospital
Dublin, Ireland
- Residency
1985
University College Dublin
Ireland
MB BCh BAO - Medicine
1982
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma. Cancer Discov. 2025 Feb 07; 15(2):401-426.
PMID: 39476412
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.
Tobacco smoking induces metabolic reprogramming of renal cell carcinoma. J Clin Invest. 2021 01 04; 131(1).
PMID: 32970633
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 02; 25(2):301-311.
PMID: 30643286
Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant.
Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant. Exp Hematol Oncol. 2019; 8:1.
PMID: 30622841
CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs.
CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs. Bioinformatics. 2018 09 01; 34(17):i664-i670.
PMID: 30423099
Development of a stress response therapy targeting aggressive prostate cancer.
Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 05 02; 10(439).
PMID: 29720449
Immune Reconstitution Following Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma at the Time of Immunotherapy.
Immune Reconstitution Following Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma at the Time of Immunotherapy. Biol Blood Marrow Transplant. 2018 03; 24(3):452-459.
PMID: 29191664
Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma.
Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma. BMC Syst Biol. 2017 Oct 03; 11(Suppl 5):92.
PMID: 28984200
Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings.
Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings. Pediatr Pulmonol. 2017 Nov; 52(11):1478-1485.
PMID: 28486752
A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature).
A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature). Sci Rep. 2017 03 03; 7(1):41.
PMID: 28246384
Bucksbaum Senior Fellow
Bucksbaum Institute, University of Chicago
2017 - 2019
George M. Eisenberg Professor
University of Chicago
2017 - 2019
Pritzker Professor
University of Chicago
2015 - 2017
Fogarty Fellowship
National Institutes of Health
1991 - 1993
Wellcome Fellowship
Wellcome Trust
1988 - 1991