Victoria E. Prince

Research Summary
My research program at the University of Chicago focuses on vertebrate axial regionalization during development using the zebrafish as a model. My group takes a variety of molecular, cellular and genetic approaches to these studies, and we have made important contributions to a variety of research areas, including the understanding of Hox gene regulation of hindbrain patterning, evolution of duplicated genes and genomes in the vertebrates, and patterning of endoderm-derived tissues. Active areas of research in my lab include continuing studies of hindbrain patterning, with an emphasis on understanding neuronal and neural crest migration.
Education
  • Imperial College, London University, London, BS Biochemistry 06/1986
  • University College, London University, London, PhD Molecular Biology 01/1991
  • University of London, Guy's Hospital, London, Postdoc Developmental Neuro 06/1994
  • Princeton University, Princeton, NJ, Postdoc Developmental Bio 07/1997
Awards & Honors
  • 1992 - 1994 Medical Research Council (UK) Training Fellowship
  • 1994 - 1995 EMBO Long-Term Fellowship Princeton University
  • 1995 - 1997 HUman Frontiers Science Program Fellowship Princeton University
  • 2005 - 2005 The Christianna Smith Lecturer Mount Holyoke College
  • 2005 - 2010 Faculty of 1000
  • 2006 - 2006 J &J Neubauer Faculty Development Fellowship in recognition of teaching excellence in the College University of Chicago
  • 2010 - 2011 Academic Leadership Fellowship CIC/University of Chicago
  • 2015 - 2018 Marshal of the University The University of Chicago
  • 2016 - 2016 Faculty Leadership Award in Program Innovation University of Chicago
Publications
  1. Rocha M, Singh N, Ahsan K, Beiriger A, Prince VE. Neural crest development: insights from the zebrafish. Dev Dyn. 2019 Oct 08. View in: PubMed

  2. Ahsan K, Singh N, Rocha M, Huang C, Prince VE. Prickle1 is required for EMT and migration of zebrafish cranial neural crest. Dev Biol. 2019 04 01; 448(1):16-35. View in: PubMed

  3. Prince VE, Anderson RM, Dalgin G. Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies. Curr Top Dev Biol. 2017; 124:235-276. View in: PubMed

  4. Dalgin G, Prince VE. Differential levels of Neurod establish zebrafish endocrine pancreas cell fates. Dev Biol. 2015 Jun 01; 402(1):81-97. View in: PubMed

  5. Love CE, Prince VE. Rest represses maturation within migrating facial branchiomotor neurons. Dev Biol. 2015 May 15; 401(2):220-35. View in: PubMed

  6. Eames SC, Kinkel MD, Rajan S, Prince VE, Philipson LH. Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig. 2013 Mar 18; 4(2):157-67. View in: PubMed

  7. Wanner SJ, Saeger I, Guthrie S, Prince VE. Facial motor neuron migration advances. Curr Opin Neurobiol. 2013 Dec; 23(6):943-50. View in: PubMed

  8. Wanner SJ, Prince VE. Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain. Development. 2013 Feb; 140(4):906-15. View in: PubMed

  9. Kok FO, Taibi A, Wanner SJ, Xie X, Moravec CE, Love CE, Prince VE, Mumm JS, Sirotkin HI. Zebrafish rest regulates developmental gene expression but not neurogenesis. Development. 2012 Oct; 139(20):3838-48. View in: PubMed

  10. Dalgin G, Prince VE. Mnx1: a gatekeeper of ß cell fate. Islets. 2012 Jul-Aug; 4(4):320-2. View in: PubMed

  11. Love CE, Prince VE. Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes. Dev Dyn. 2012 Oct; 241(10):1603-15. View in: PubMed

  12. Dalgin G, Ward AB, Hao le T, Beattie CE, Nechiporuk A, Prince VE. Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development. 2011 Nov; 138(21):4597-608. View in: PubMed

  13. Mapp OM, Walsh GS, Moens CB, Tada M, Prince VE. Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity. Development. 2011 May; 138(10):2121-32. View in: PubMed

  14. Kinkel MD, Eames SC, Philipson LH, Prince VE. Intraperitoneal injection into adult zebrafish. J Vis Exp. 2010 Aug 30; (42). View in: PubMed

  15. Eames SC, Philipson LH, Prince VE, Kinkel MD. Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish. 2010 Jun; 7(2):205-13. View in: PubMed

  16. Mapp OM, Wanner SJ, Rohrschneider MR, Prince VE. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Dev Dyn. 2010 Jun; 239(6):1596-608. View in: PubMed

  17. Prince VE, Kinkel MD. Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cells. F1000 Biol Rep. 2010; 2:17. View in: PubMed

  18. Rajan S, Eames SC, Park SY, Labno C, Bell GI, Prince VE, Philipson LH. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E403-10. View in: PubMed

  19. Bingham SM, Sittaramane V, Mapp O, Patil S, Prince VE, Chandrasekhar A. Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Dev Neurobiol. 2010 Feb; 70(2):87-99. View in: PubMed

  20. Aldinger KA, Elsen GE, Prince VE, Millen KJ. Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain. Semin Pediatr Neurol. 2009 Sep; 16(3):155-63. View in: PubMed

  21. Elsen GE, Choi LY, Prince VE, Ho RK. The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol. 2009 Nov 01; 335(1):78-92. View in: PubMed

  22. Kinkel MD, Sefton EM, Kikuchi Y, Mizoguchi T, Ward AB, Prince VE. Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7864-9. View in: PubMed

  23. Kinkel MD, Prince VE. On the diabetic menu: zebrafish as a model for pancreas development and function. Bioessays. 2009 Feb; 31(2):139-52. View in: PubMed

  24. Skromne I, Prince VE. Current perspectives in zebrafish reverse genetics: moving forward. Dev Dyn. 2008 Apr; 237(4):861-82. View in: PubMed

  25. Kinkel MD, Eames SC, Alonzo MR, Prince VE. Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number. Development. 2008 Mar; 135(5):919-29. View in: PubMed

  26. Elsen GE, Choi LY, Millen KJ, Grinblat Y, Prince VE. Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Dev Biol. 2008 Feb 15; 314(2):376-92. View in: PubMed

  27. Hurley IA, Scemama JL, Prince VE. Consequences of hoxb1 duplication in teleost fish. Evol Dev. 2007 Nov-Dec; 9(6):540-54. View in: PubMed

  28. Rohrschneider MR, Elsen GE, Prince VE. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007 Sep 15; 309(2):358-72. View in: PubMed

  29. Skromne I, Thorsen D, Hale M, Prince VE, Ho RK. Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development. 2007 Jun; 134(11):2147-58. View in: PubMed

  30. Hurley IA, Mueller RL, Dunn KA, Schmidt EJ, Friedman M, Ho RK, Prince VE, Yang Z, Thomas MG, Coates MI. A new time-scale for ray-finned fish evolution. Proc Biol Sci. 2007 Feb 22; 274(1609):489-98. View in: PubMed

  31. Ward AB, Warga RM, Prince VE. Origin of the zebrafish endocrine and exocrine pancreas. Dev Dyn. 2007 Jun; 236(6):1558-69. View in: PubMed

  32. Hadrys T, Punnamoottil B, Pieper M, Kikuta H, Pezeron G, Becker TS, Prince V, Baker R, Rinkwitz S. Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Dev Biol. 2006 Sep 01; 297(1):26-43. View in: PubMed

  33. Stafford D, White RJ, Kinkel MD, Linville A, Schilling TF, Prince VE. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development. 2006 Mar; 133(5):949-56. View in: PubMed

  34. Hurley I, Hale ME, Prince VE. Duplication events and the evolution of segmental identity. Evol Dev. 2005 Nov-Dec; 7(6):556-67. View in: PubMed

  35. Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince VE, Lieschke GJ. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Dev Biol. 2004 Dec 15; 276(2):508-22. View in: PubMed

  36. Stafford D, Hornbruch A, Mueller PR, Prince VE. A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol. 2004 Sep; 214(9):432-41. View in: PubMed

  37. Hadrys T, Prince V, Hunter M, Baker R, Rinkwitz S. Comparative genomic analysis of vertebrate Hox3 and Hox4 genes. J Exp Zool B Mol Dev Evol. 2004 Mar 15; 302(2):147-64. View in: PubMed

  38. Hale ME, Kheirbek MA, Schriefer JE, Prince VE. Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. J Neurosci. 2004 Mar 24; 24(12):3070-6. View in: PubMed

  39. Jozefowicz C, McClintock J, Prince V. The fates of zebrafish Hox gene duplicates. J Struct Funct Genomics. 2003; 3(1-4):185-94. View in: PubMed

  40. McClintock JM, Jozefowicz C, Assimacopoulos S, Grove EA, Louvi A, Prince VE. Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. Dev Genes Evol. 2003 Aug; 213(8):399-406. View in: PubMed

  41. Prince VE, Pickett FB. Splitting pairs: the diverging fates of duplicated genes. Nat Rev Genet. 2002 Nov; 3(11):827-37. View in: PubMed

  42. Scemama JL, Hunter M, McCallum J, Prince V, Stellwag E. Evolutionary divergence of vertebrate Hoxb2 expression patterns and transcriptional regulatory loci. J Exp Zool. 2002 Oct 15; 294(3):285-99. View in: PubMed

  43. Prince V. The Hox Paradox: More complex(es) than imagined. Dev Biol. 2002 Sep 01; 249(1):1-15. View in: PubMed

  44. Stafford D, Prince VE. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol. 2002 Jul 23; 12(14):1215-20. View in: PubMed

  45. Hunter MP, Prince VE. Zebrafish hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch. Dev Biol. 2002 Jul 15; 247(2):367-89. View in: PubMed

  46. Moens CB, Prince VE. Constructing the hindbrain: insights from the zebrafish. Dev Dyn. 2002 May; 224(1):1-17. View in: PubMed

  47. McClintock JM, Kheirbek MA, Prince VE. Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development. 2002 May; 129(10):2339-54. View in: PubMed

  48. Hauptmann G, Belting HG, Wolke U, Lunde K, Söll I, Abdelilah-Seyfried S, Prince V, Driever W. spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development. 2002 Apr; 129(7):1645-55. View in: PubMed

  49. McClintock JM, Carlson R, Mann DM, Prince VE. Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes. Development. 2001 Jul; 128(13):2471-84. View in: PubMed

  50. Bruce AE, Oates AC, Prince VE, Ho RK. Additional hox clusters in the zebrafish: divergent expression patterns belie equivalent activities of duplicate hoxB5 genes. Evol Dev. 2001 May-Jun; 3(3):127-44. View in: PubMed

  51. Prince VE, Holley SA, Bally-Cuif L, Prabhakaran B, Oates AC, Ho RK, Vogt TF. Zebrafish lunatic fringe demarcates segmental boundaries. Mech Dev. 2001 Jul; 105(1-2):175-80. View in: PubMed

  52. Zerucha T, Prince VE. Cloning and developmental expression of a zebrafish meis2 homeobox gene. Mech Dev. 2001 Apr; 102(1-2):247-50. View in: PubMed

  53. Schilling TF, Prince V, Ingham PW. Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Dev Biol. 2001 Mar 01; 231(1):201-16. View in: PubMed

  54. Patel NH, Prince VE. Beyond the Hox complex. Genome Biol. 2000; 1(5):REVIEWS1027. View in: PubMed

  55. Roy MN, Prince VE, Ho RK. Heat shock produces periodic somitic disturbances in the zebrafish embryo. Mech Dev. 1999 Jul; 85(1-2):27-34. View in: PubMed

  56. Amores A, Force A, Yan YL, Joly L, Amemiya C, Fritz A, Ho RK, Langeland J, Prince V, Wang YL, Westerfield M, Ekker M, Postlethwait JH. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998 Nov 27; 282(5394):1711-4. View in: PubMed

  57. Prince VE, Price AL, Ho RK. Hox gene expression reveals regionalization along the anteroposterior axis of the zebrafish notochord. Dev Genes Evol. 1998 Nov; 208(9):517-22. View in: PubMed

  58. Prince VE, Joly L, Ekker M, Ho RK. Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk. Development. 1998 Feb; 125(3):407-20. View in: PubMed

  59. Prince VE, Moens CB, Kimmel CB, Ho RK. Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino. Development. 1998 Feb; 125(3):393-406. View in: PubMed

  60. Gale E, Prince V, Lumsden A, Clarke J, Holder N, Maden M. Late effects of retinoic acid on neural crest and aspects of rhombomere. Development. 1996 Mar; 122(3):783-93. View in: PubMed

  61. Guthrie S, Prince V, Lumsden A. Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts. Development. 1993 Jun; 118(2):527-38. View in: PubMed

  62. Prince V, Lumsden A. Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest. Development. 1994 Apr; 120(4):911-23. View in: PubMed

  63. Prince VE, Rigby PW. Derivatives of Moloney murine sarcoma virus capable of being transcribed in embryonal carcinoma stem cells have gained a functional Sp1 binding site. J Virol. 1991 Apr; 65(4):1803-11. View in: PubMed